Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

[Image: see text] Small-molecule-induced protein depletion technologies, also called inducible degrons, allow degradation of genetically engineered target proteins within cells and animals. Here, we design and develop the BromoTag, a new inducible degron system comprising a Brd4 bromodomain L387A va...

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Detalles Bibliográficos
Autores principales: Bond, Adam G., Craigon, Conner, Chan, Kwok-Ho, Testa, Andrea, Karapetsas, Athanasios, Fasimoye, Rotimi, Macartney, Thomas, Blow, J. Julian, Alessi, Dario R., Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558867/
https://www.ncbi.nlm.nih.gov/pubmed/34652918
http://dx.doi.org/10.1021/acs.jmedchem.1c01532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558867/
https://www.ncbi.nlm.nih.gov/pubmed/34652918
http://dx.doi.org/10.1021/acs.jmedchem.1c01532

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