Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes

BACKGROUND: Esophageal adenocarcinoma (EAC) is an aggressive malignancy with a poor prognosis. The immune-related genes (IRGs) are crucial to immunocytes tumor infiltration. This study aimed to construct a IRG-related prediction signature in EAC. METHODS: The related data of EAC patients and IRGs we...

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Autores principales: Zhang, Xiangxin, Yang, Liu, Kong, Ming, Ma, Jian, Wei, Yutao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559413/
https://www.ncbi.nlm.nih.gov/pubmed/34724890
http://dx.doi.org/10.1186/s12859-021-04456-2
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author Zhang, Xiangxin
Yang, Liu
Kong, Ming
Ma, Jian
Wei, Yutao
author_facet Zhang, Xiangxin
Yang, Liu
Kong, Ming
Ma, Jian
Wei, Yutao
author_sort Zhang, Xiangxin
collection PubMed
description BACKGROUND: Esophageal adenocarcinoma (EAC) is an aggressive malignancy with a poor prognosis. The immune-related genes (IRGs) are crucial to immunocytes tumor infiltration. This study aimed to construct a IRG-related prediction signature in EAC. METHODS: The related data of EAC patients and IRGs were obtained from the TCGA and ImmPort database, respectively. The cox regression analysis constructed the prediction signature and explored the transcription factors regulatory network through the Cistrome database. TIMER database and CIBERSORT analytical tool were utilized to explore the immunocytes infiltration analysis. RESULTS: The prediction signature with 12 IRGs (ADRM1, CXCL1, SEMG1, CCL26, CCL24, AREG, IL23A, UCN2, FGFR4, IL17RB, TNFRSF11A, and TNFRSF21) was constructed. Overall survival (OS) curves indicate that the survival rate of the high-risk group is significantly shorter than the low-risk group (P = 7.26e−07), and the AUC of 1-, 3- and 5- year survival prediction rates is 0.871, 0.924, and 0.961, respectively. Compared with traditional features, the ROC curve of the risk score in the EAC patients (0.967) is significant than T (0.57), N (0.738), M (0.568), and Stage (0.768). Moreover, multivariate Cox analysis and Nomogram of risk score are indicated that the 1-year and 3-year survival rates of patients are accurate by the combined analysis of the risk score, Sex, M stage, and Stage (The AUC of 1- and 3-years are 0.911, and 0.853). CONCLUSION: The 12 prognosis-related IRGs might be promising therapeutic targets for EAC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-021-04456-2.
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spelling pubmed-85594132021-11-03 Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes Zhang, Xiangxin Yang, Liu Kong, Ming Ma, Jian Wei, Yutao BMC Bioinformatics Research BACKGROUND: Esophageal adenocarcinoma (EAC) is an aggressive malignancy with a poor prognosis. The immune-related genes (IRGs) are crucial to immunocytes tumor infiltration. This study aimed to construct a IRG-related prediction signature in EAC. METHODS: The related data of EAC patients and IRGs were obtained from the TCGA and ImmPort database, respectively. The cox regression analysis constructed the prediction signature and explored the transcription factors regulatory network through the Cistrome database. TIMER database and CIBERSORT analytical tool were utilized to explore the immunocytes infiltration analysis. RESULTS: The prediction signature with 12 IRGs (ADRM1, CXCL1, SEMG1, CCL26, CCL24, AREG, IL23A, UCN2, FGFR4, IL17RB, TNFRSF11A, and TNFRSF21) was constructed. Overall survival (OS) curves indicate that the survival rate of the high-risk group is significantly shorter than the low-risk group (P = 7.26e−07), and the AUC of 1-, 3- and 5- year survival prediction rates is 0.871, 0.924, and 0.961, respectively. Compared with traditional features, the ROC curve of the risk score in the EAC patients (0.967) is significant than T (0.57), N (0.738), M (0.568), and Stage (0.768). Moreover, multivariate Cox analysis and Nomogram of risk score are indicated that the 1-year and 3-year survival rates of patients are accurate by the combined analysis of the risk score, Sex, M stage, and Stage (The AUC of 1- and 3-years are 0.911, and 0.853). CONCLUSION: The 12 prognosis-related IRGs might be promising therapeutic targets for EAC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-021-04456-2. BioMed Central 2021-11-01 /pmc/articles/PMC8559413/ /pubmed/34724890 http://dx.doi.org/10.1186/s12859-021-04456-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Xiangxin
Yang, Liu
Kong, Ming
Ma, Jian
Wei, Yutao
Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
title Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
title_full Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
title_fullStr Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
title_full_unstemmed Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
title_short Development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
title_sort development of a prognostic signature of patients with esophagus adenocarcinoma by using immune-related genes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559413/
https://www.ncbi.nlm.nih.gov/pubmed/34724890
http://dx.doi.org/10.1186/s12859-021-04456-2
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