A mixture model for signature discovery from sparse mutation data

Mutational signatures are key to understanding the processes that shape cancer genomes, yet their analysis requires relatively rich whole-genome or whole-exome mutation data. Recently, orders-of-magnitude sparser gene-panel-sequencing data have become increasingly available in the clinic. To deal wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sason, Itay, Chen, Yuexi, Leiserson, Mark D.M., Sharan, Roded
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559697/
https://www.ncbi.nlm.nih.gov/pubmed/34724984
http://dx.doi.org/10.1186/s13073-021-00988-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559697/
https://www.ncbi.nlm.nih.gov/pubmed/34724984
http://dx.doi.org/10.1186/s13073-021-00988-7

Ejemplares similares