SMAD4 is Critical in Suppression of BRAF-V600E Serrated Tumorigenesis

BRAF-driven colorectal cancer is among the poorest prognosis subtypes of colon cancer. Previous studies suggest that BRAF-mutant serrated cancers frequently exhibit Microsatellite Instability (MSI) and elevated levels of WNT signaling. Loss of tumor-suppressor Smad4 in oncogenic BRAF-V600E mouse mod...

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Detalles Bibliográficos
Autores principales: Tong, Kevin, Kothari, Om A., Haro, Katherine S., Panda, Anshuman, Bandari, Manisha M., Carrick, Jillian N., Hur, Joseph J., Zhang, Lanjing, Chan, Chang S., Xing, Jinchuan, Gatza, Michael L., Ganesan, Shridar, Verzi, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559887/
https://www.ncbi.nlm.nih.gov/pubmed/34453124
http://dx.doi.org/10.1038/s41388-021-01997-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559887/
https://www.ncbi.nlm.nih.gov/pubmed/34453124
http://dx.doi.org/10.1038/s41388-021-01997-x

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