Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila

SF3B1 mutations occur in many cancers, and the highly conserved His662 residue is one of the hotspot mutation sites. To address effects on splicing and development, we constructed strains carrying point mutations at the corresponding residue His698 in Drosophila using the CRISPR-Cas9 technique. Two...

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Detalles Bibliográficos
Autores principales: Zhang, Bei, Ding, Zhan, Li, Liang, Xie, Ling-Kun, Fan, Yu-Jie, Xu, Yong-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559932/
https://www.ncbi.nlm.nih.gov/pubmed/34723968
http://dx.doi.org/10.1371/journal.pgen.1009861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559932/
https://www.ncbi.nlm.nih.gov/pubmed/34723968
http://dx.doi.org/10.1371/journal.pgen.1009861

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