AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord

AAV vectors are being used extensively for gene-modifying therapies for neurological disorders. Here, we report the surprising discovery that injections of different AAVs into the brain, spinal cord, or cerebrospinal fluid (CSF) lead to robust transduction of cells in the pineal gland. We document t...

Descripción completa

Detalles Bibliográficos
Autores principales: Steward, Oswald, Coulibaly, Aminata P., Metcalfe, Mariajose, Dam, Jamie M., Yee, Kelly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560646/
https://www.ncbi.nlm.nih.gov/pubmed/34761054
http://dx.doi.org/10.1016/j.omtm.2021.09.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560646/
https://www.ncbi.nlm.nih.gov/pubmed/34761054
http://dx.doi.org/10.1016/j.omtm.2021.09.016

Ejemplares similares