Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis. This reaction is catalyzed by peptidyl arginine deiminases (PADs), of which PAD2 and PAD4 are thought to play key pathogenic roles. S...

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Detalles Bibliográficos
Autores principales: Martín Monreal, María Teresa, Rebak, Alexandra Stripp, Massarenti, Laura, Mondal, Santanu, Šenolt, Ladislav, Ødum, Niels, Nielsen, Michael L., Thompson, Paul R., Nielsen, Claus H., Damgaard, Dres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560728/
https://www.ncbi.nlm.nih.gov/pubmed/34737738
http://dx.doi.org/10.3389/fimmu.2021.716250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560728/
https://www.ncbi.nlm.nih.gov/pubmed/34737738
http://dx.doi.org/10.3389/fimmu.2021.716250

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