Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1

Cancer linked isocitrate dehydrogenase (IDH) 1 variants, notably R132H IDH1, manifest a ‘gain-of-function’ to reduce 2-oxoglutarate to 2-hydroxyglutarate. High-throughput screens have enabled clinically useful R132H IDH1 inhibitors, mostly allosteric binders at the dimer interface. We report investi...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Abboud, Martine I., John, Tobias, Mikhailov, Victor, Hvinden, Ingvild, Walsby-Tickle, John, Liu, Xiao, Pettinati, Ilaria, Cadoux-Hudson, Tom, McCullagh, James S. O., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560763/
https://www.ncbi.nlm.nih.gov/pubmed/34725432
http://dx.doi.org/10.1038/s42003-021-02743-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560763/
https://www.ncbi.nlm.nih.gov/pubmed/34725432
http://dx.doi.org/10.1038/s42003-021-02743-5

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