Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. Here we compare intracellular traffic of anti KRAS antisense oligonucleotide (AZD4785) i...

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Detalles Bibliográficos
Autores principales: Kapustin, Alexander N., Davey, Paul, Longmire, David, Matthews, Carl, Linnane, Emily, Rustogi, Nitin, Stavrou, Maria, Devine, Paul W. A., Bond, Nicholas J., Hanson, Lyndsey, Sonzini, Silvia, Revenko, Alexey, MacLeod, A. Robert, Ross, Sarah, Chiarparin, Elisabetta, Puri, Sanyogitta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560811/
https://www.ncbi.nlm.nih.gov/pubmed/34725463
http://dx.doi.org/10.1038/s42003-021-02772-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560811/
https://www.ncbi.nlm.nih.gov/pubmed/34725463
http://dx.doi.org/10.1038/s42003-021-02772-0

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