Dynamic interactions and Ca(2+)-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding

The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin mediators aggravates disease at late...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreira, Guilherme G., Cantrelle, François-Xavier, Quezada, Andrea, Carvalho, Filipa S., Cristóvão, Joana S., Sengupta, Urmi, Puangmalai, Nicha, Carapeto, Ana P., Rodrigues, Mário S., Cardoso, Isabel, Fritz, Güenter, Herrera, Federico, Kayed, Rakez, Landrieu, Isabelle, Gomes, Cláudio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560819/
https://www.ncbi.nlm.nih.gov/pubmed/34725360
http://dx.doi.org/10.1038/s41467-021-26584-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560819/
https://www.ncbi.nlm.nih.gov/pubmed/34725360
http://dx.doi.org/10.1038/s41467-021-26584-2

Ejemplares similares