Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody

Angiopoietin (Angpt)-Tie receptor 2 (Tie2) plays key roles in vascular development and homeostasis as well as pathological vascular remodeling. Therefore, Tie2-agonistic antibody and engineered Angpt1 variants have been developed as potential therapeutics for ischemic and inflammatory vascular disea...

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Detalles Bibliográficos
Autores principales: Jo, Gyunghee, Bae, Jeomil, Hong, Ho Jeong, Han, Ah-reum, Kim, Do-Kyun, Hong, Seon Pyo, Kim, Jung A, Lee, Sangkyu, Koh, Gou Young, Kim, Ho Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560823/
https://www.ncbi.nlm.nih.gov/pubmed/34725372
http://dx.doi.org/10.1038/s41467-021-26620-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560823/
https://www.ncbi.nlm.nih.gov/pubmed/34725372
http://dx.doi.org/10.1038/s41467-021-26620-1

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