Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences

The design of superior biologic therapeutics, including antibodies and engineered proteins, involves optimizing their specific ability to bind to disease-related molecular targets. Previously, we developed and applied the Assisted Design of Antibody and Protein Therapeutics (ADAPT) platform for virt...

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Detalles Bibliográficos
Autores principales: Corbeil, Christopher R., Manenda, Mahder Seifu, Sulea, Traian, Baardsnes, Jason, Picard, Marie-Ève, Hogues, Hervé, Gaudreault, Francis, Deprez, Christophe, Shi, Rong, Purisima, Enrico O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560851/
https://www.ncbi.nlm.nih.gov/pubmed/34725391
http://dx.doi.org/10.1038/s41598-021-00669-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560851/
https://www.ncbi.nlm.nih.gov/pubmed/34725391
http://dx.doi.org/10.1038/s41598-021-00669-w

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