Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia

Rare, yet biologically critical, lipids that contain very long chain fatty acids (VLCFA-lipids) are synthesized in the brain by the enzyme ELOVL4. High levels of VLCFA-lipids are toxic to cells and excess VLCFA-lipids are actively removed by ABCD1 in an ATP-dependent manner. Virtually nothing is kno...

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Detalles Bibliográficos
Autores principales: He, Ying, Phan, Katherine, Bhatia, Surabhi, Pickford, Russell, Fu, YuHong, Yang, Yue, Hodges, John R., Piguet, Olivier, Halliday, Glenda M., Kim, Woojin Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560873/
https://www.ncbi.nlm.nih.gov/pubmed/34725421
http://dx.doi.org/10.1038/s41598-021-00870-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560873/
https://www.ncbi.nlm.nih.gov/pubmed/34725421
http://dx.doi.org/10.1038/s41598-021-00870-x

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