Cargando…

Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia

Rare, yet biologically critical, lipids that contain very long chain fatty acids (VLCFA-lipids) are synthesized in the brain by the enzyme ELOVL4. High levels of VLCFA-lipids are toxic to cells and excess VLCFA-lipids are actively removed by ABCD1 in an ATP-dependent manner. Virtually nothing is kno...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Ying, Phan, Katherine, Bhatia, Surabhi, Pickford, Russell, Fu, YuHong, Yang, Yue, Hodges, John R., Piguet, Olivier, Halliday, Glenda M., Kim, Woojin Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560873/ https://www.ncbi.nlm.nih.gov/pubmed/34725421 http://dx.doi.org/10.1038/s41598-021-00870-x

Ejemplares similares

Uncovering pathophysiological changes in frontotemporal dementia using serum lipids
por: Phan, Katherine, et al.
Publicado: (2020)

Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
por: Fu, YuHong, et al.
Publicado: (2022)

Lipidomics Analysis of Behavioral Variant Frontotemporal Dementia: A Scope for Biomarker Development
por: Kim, Woojin Scott, et al.
Publicado: (2018)

Eating peptides: biomarkers of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia
por: Ahmed, Rebekah M., et al.
Publicado: (2019)

Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
por: Phan, Katherine, et al.
Publicado: (2021)

Glycoprotein Pathways Altered in Frontotemporal Dementia With Autoimmune Disease
por: Bright, Fiona, et al.
Publicado: (2021)

Apolipoprotein D Upregulation in Alzheimer’s Disease but Not Frontotemporal Dementia
por: Bhatia, Surabhi, et al.
Publicado: (2018)

Altered High Density Lipoprotein Composition in Behavioral Variant Frontotemporal Dementia
por: Kim, Woojin Scott, et al.
Publicado: (2018)

Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia
por: Lok, Hiu Chuen, et al.
Publicado: (2023)

ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions
por: Katzeff, Jared S., et al.
Publicado: (2022)

Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis
por: Katzeff, Jared S., et al.
Publicado: (2022)

Eating and hypothalamus changes in behavioral-variant frontotemporal dementia
por: Piguet, Olivier, et al.
Publicado: (2011)

Behavioural-variant frontotemporal dementia: an update
por: Piguet, Olivier, et al.
Publicado: (2013)

Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis
por: Phan, Katherine, et al.
Publicado: (2022)

Progress and Challenges in Frontotemporal Dementia Research: A 20-Year Review
por: Hodges, John R., et al.
Publicado: (2018)

Distinct disease trajectories in frontotemporal dementia–motor neuron disease and behavioural variant frontotemporal dementia: A longitudinal study
por: Long, Zhe, et al.
Publicado: (2022)

Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation
por: Katzeff, Jared S., et al.
Publicado: (2020)

Distinct hypothalamic involvement in the amyotrophic lateral sclerosis-frontotemporal dementia spectrum
por: Tse, Nga Yan, et al.
Publicado: (2022)

Discrete Neural Correlates for the Recognition of Negative Emotions: Insights from Frontotemporal Dementia
por: Kumfor, Fiona, et al.
Publicado: (2013)

Schizotypal traits across the amyotrophic lateral sclerosis–frontotemporal dementia spectrum: pathomechanistic insights
por: Tse, Nga Yan, et al.
Publicado: (2022)

Examining the presence and nature of delusions in Alzheimer's disease and frontotemporal dementia syndromes
por: Kumfor, Fiona, et al.
Publicado: (2022)

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model
por: Dang, Theresa N. T., et al.
Publicado: (2013)

Heritability in frontotemporal tauopathies
por: Forrest, Shelley L., et al.
Publicado: (2019)

Frontal and temporal lobe contributions to emotional enhancement of memory in behavioral-variant frontotemporal dementia and Alzheimer's disease
por: Kumfor, Fiona, et al.
Publicado: (2014)

Sex-specific lipid dysregulation in the Abca7 knockout mouse brain
por: Fu, YuHong, et al.
Publicado: (2022)

Longitudinal change in everyday function and behavioral symptoms in frontotemporal dementia
por: O'Connor, Claire M., et al.
Publicado: (2016)

Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum
por: Tan, Rachel H., et al.
Publicado: (2014)

Tackling clinical heterogeneity across the amyotrophic lateral sclerosis–frontotemporal dementia spectrum using a transdiagnostic approach
por: Ahmed, Rebekah M, et al.
Publicado: (2021)

Terra incognita—cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia
por: Tan, Rachel H., et al.
Publicado: (2015)

Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia
por: Ramanan, Siddharth, et al.
Publicado: (2023)

Impaired acquisition rates of probabilistic associative learning in frontotemporal dementia is associated with fronto-striatal atrophy()
por: Dalton, Marshall A., et al.
Publicado: (2012)

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
por: Radford, Helois, et al.
Publicado: (2015)

All Is Not Lost: Positive Behaviors in Alzheimer’s Disease and Behavioral-Variant Frontotemporal Dementia with Disease Severity
por: Midorikawa, Akira, et al.
Publicado: (2016)

Behavioral-variant frontotemporal dementia: Distinct phenotypes with unique functional profiles
por: O'Connor, Claire M., et al.
Publicado: (2017)

Neural networks associated with body composition in frontotemporal dementia
por: Ahmed, Rebekah M., et al.
Publicado: (2019)

Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer’s disease
por: Manuel, Aurélie L, et al.
Publicado: (2020)

Factors Underpinning Caregiver Burden in Frontotemporal Dementia Differ in Spouses and their Children
por: Kaizik, Cassandra, et al.
Publicado: (2017)

APP‐derived peptides reflect neurodegeneration in frontotemporal dementia
por: Illán‐Gala, Ignacio, et al.
Publicado: (2019)

Deletion of Alzheimer’s Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels
por: Bhatia, Surabhi, et al.
Publicado: (2017)

Differences in Sex Distribution Between Genetic and Sporadic Frontotemporal Dementia
por: de Boer, Sterre C.M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2dbnomnpmc3vken6faqpr67al8