Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells

Anchorage-independent growth of cancer cells in vitro is correlated to metastasis formation in vivo. Metformin use is associated with decreased breast cancer incidence and currently evaluated in cancer clinical trials. The combined treatment with metformin and 2-deoxy-D-glucose (2DG) in vitro induce...

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Detalles Bibliográficos
Autores principales: Repas, Jernej, Zügner, Elmar, Gole, Boris, Bizjak, Maruša, Potočnik, Uroš, Magnes, Christoph, Pavlin, Mojca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560930/
https://www.ncbi.nlm.nih.gov/pubmed/34725457
http://dx.doi.org/10.1038/s41598-021-98642-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560930/
https://www.ncbi.nlm.nih.gov/pubmed/34725457
http://dx.doi.org/10.1038/s41598-021-98642-0

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