Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies

T cells engineered with chimeric antigen receptor (CAR-T cells) are an effective treatment in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia or B-cell non-Hodgkin lymphoma. Despite the reported exciting clinical results, the CAR-T cell approach needs efforts to impro...

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Detalles Bibliográficos
Autores principales: Guercio, Marika, Manni, Simona, Boffa, Iolanda, Caruso, Simona, Di Cecca, Stefano, Sinibaldi, Matilde, Abbaszadeh, Zeinab, Camera, Antonio, Ciccone, Roselia, Polito, Vinicia Assunta, Ferrandino, Francesca, Reddel, Sofia, Catanoso, Maria Luigia, Bocceri, Emilia, Del Bufalo, Francesca, Algeri, Mattia, De Angelis, Biagio, Quintarelli, Concetta, Locatelli, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560965/
https://www.ncbi.nlm.nih.gov/pubmed/34737753
http://dx.doi.org/10.3389/fimmu.2021.755639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560965/
https://www.ncbi.nlm.nih.gov/pubmed/34737753
http://dx.doi.org/10.3389/fimmu.2021.755639

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