Effect of CYP3A4 Inhibitors and Inducers on Pharmacokinetics and Pharmacodynamics of Saxagliptin and Active Metabolite M2 in Humans Using Physiological-Based Pharmacokinetic Combined DPP-4 Occupancy

We aimed to develop a physiological-based pharmacokinetic and dipepidyl peptidase 4 (DPP-4) occupancy model (PBPK-DO) characterized by two simultaneous simulations to predict pharmacokinetic (PK) and pharmacodynamic changes of saxagliptin and metabolite M2 in humans when coadministered with CYP3A4 i...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Gang, Yi, Bowen, Liu, Jingtong, Jiang, Xiaoquan, Pan, Fulu, Yang, Wenning, Liu, Haibo, Liu, Yang, Wang, Guopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560969/
https://www.ncbi.nlm.nih.gov/pubmed/34737703
http://dx.doi.org/10.3389/fphar.2021.746594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560969/
https://www.ncbi.nlm.nih.gov/pubmed/34737703
http://dx.doi.org/10.3389/fphar.2021.746594

Ejemplares similares