The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation

Zinc deficiency has been linked to human diseases, including cancer. MDMX, a crucial zinc-containing negative regulator of p53, has been found to be amplified or overexpressed in various cancers and implicated in the cancer initiation and progression. We report here that zinc depletion by the ion ch...

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Detalles Bibliográficos
Autores principales: Wang, Herui, Li, Bin, Asha, Kulsum, Pangilinan, Ryan L., Thuraisamy, Asha, Chopra, Harman, Rokudai, Susumu, Yu, Yong, Prives, Carol L., Zhu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561006/
https://www.ncbi.nlm.nih.gov/pubmed/34627839
http://dx.doi.org/10.1016/j.jbc.2021.101292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561006/
https://www.ncbi.nlm.nih.gov/pubmed/34627839
http://dx.doi.org/10.1016/j.jbc.2021.101292

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