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Solvent-free synthesis of enantioenriched β-silyl nitroalkanes under organocatalytic conditions
An enantioselective 1,4-conjugate addition of nitromethane to β-silyl α,β-unsaturated carbonyl compounds catalyzed by bifunctional squaramide catalysts has been developed. This methodology offers both enantiomers of β-silyl nitroalkanes in good to excellent yields (up to 92%) and enantioselectivitie...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561140/ https://www.ncbi.nlm.nih.gov/pubmed/34795801 http://dx.doi.org/10.3762/bjoc.17.177 |