Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia

Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is associated with increased relapse-free survival. As 6-th...

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Detalles Bibliográficos
Autores principales: Larsen, Rikke Hebo, Rank, Cecilie Utke, Grell, Kathrine, Møller, Lisbeth Nørgaard, Overgaard, Ulrik Malthe, Kampmann, Peter, Nersting, Jacob, Degn, Matilda, Nielsen, Stine Nygaard, Holst, Helle, Albertsen, Birgitte Klug, Wehner, Peder Skov, Callesen, Michael Thude, Kanerva, Jukka, Frandsen, Thomas Leth, Als-Nielsen, Bodil, Hjalgrim, Lisa Lyngsie, Schmiegelow, Kjeld
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561300/
https://www.ncbi.nlm.nih.gov/pubmed/34047177
http://dx.doi.org/10.3324/haematol.2020.278166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561300/
https://www.ncbi.nlm.nih.gov/pubmed/34047177
http://dx.doi.org/10.3324/haematol.2020.278166

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