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SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant

Shigella spp. are highly adapted pathogens that cause bacillary dysentery in human and nonhuman primates. An unusual feature of Shigella pathogenesis is that this organism invades the colonic epithelia from the basolateral pole. Therefore, it has evolved the ability to disrupt the intestinal epithel...

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Detalles Bibliográficos
Autores principales: Meza-Segura, Mario, Birtley, James R., Maldonado-Contreras, Ana, Mueller, Christian, Simin, Karl J., Stern, Lawrence J., McCormick, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561385/
https://www.ncbi.nlm.nih.gov/pubmed/34724811
http://dx.doi.org/10.1128/mBio.02833-21