The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation

While aggregation‐prone proteins are known to accelerate aging and cause age‐related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG‐4, SERF1A, and SERF2 have recently been identified as cellular modifiers of such proteotoxicity. Using...

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Detalles Bibliográficos
Autores principales: Pras, Anita, Houben, Bert, Aprile, Francesco A, Seinstra, Renée, Gallardo, Rodrigo, Janssen, Leen, Hogewerf, Wytse, Gallrein, Christian, De Vleeschouwer, Matthias, Mata‐Cabana, Alejandro, Koopman, Mandy, Stroo, Esther, de Vries, Minke, Louise Edwards, Samantha, Kirstein, Janine, Vendruscolo, Michele, Falsone, Salvatore Fabio, Rousseau, Frederic, Schymkowitz, Joost, Nollen, Ellen A A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561633/
https://www.ncbi.nlm.nih.gov/pubmed/34617299
http://dx.doi.org/10.15252/embj.2020107568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561633/
https://www.ncbi.nlm.nih.gov/pubmed/34617299
http://dx.doi.org/10.15252/embj.2020107568

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