PBRM1 loss in kidney cancer unbalances the proximal tubule master transcription factor hub to repress proximal tubule differentiation

PBRM1, a subunit of the PBAF coactivator complex that transcription factors use to activate target genes, is genetically inactivated in almost all clear cell renal cell cancers (RCCs). Using unbiased proteomic analyses, we find that PAX8, a master transcription factor driver of proximal tubule epith...

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Detalles Bibliográficos
Autores principales: Gu, Xiaorong, Enane, Francis, Tohme, Rita, Schuerger, Caroline, Radivoyevitch, Tomas, Parker, Yvonne, Zuberi, Eric, Przychodzen, Bartlomiej, Jha, Babal Kant, Lindner, Daniel, Rini, Brian, Saunthararajah, Yogen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561673/
https://www.ncbi.nlm.nih.gov/pubmed/34551289
http://dx.doi.org/10.1016/j.celrep.2021.109747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561673/
https://www.ncbi.nlm.nih.gov/pubmed/34551289
http://dx.doi.org/10.1016/j.celrep.2021.109747

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