Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells

OBJECTIVE: Epithelial–mesenchymal transition (EMT) is involved in the development of proliferative vitreoretinopathy (PVR) and subsequent fibrosis. Previously, we demonstrated that placental extract ameliorates fibrosis in a mouse model of non-alcoholic steatohepatitis. In this study, we evaluated w...

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Autores principales: Igarashi, Kyoko, Sugimoto, Koji, Hirano, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561846/
https://www.ncbi.nlm.nih.gov/pubmed/34727968
http://dx.doi.org/10.1186/s13104-021-05824-0
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author Igarashi, Kyoko
Sugimoto, Koji
Hirano, Eiichi
author_facet Igarashi, Kyoko
Sugimoto, Koji
Hirano, Eiichi
author_sort Igarashi, Kyoko
collection PubMed
description OBJECTIVE: Epithelial–mesenchymal transition (EMT) is involved in the development of proliferative vitreoretinopathy (PVR) and subsequent fibrosis. Previously, we demonstrated that placental extract ameliorates fibrosis in a mouse model of non-alcoholic steatohepatitis. In this study, we evaluated whether placental extract influences EMT and fibrosis through cytokine-induced EMT in the retinal pigment epithelial cells, in vitro. RESULTS: Placental extract did not inhibit EMT, but it suppressed excessive mesenchymal reactions and the subsequent fibrosis. These results suggest that placental extract effectively ameliorates EMT-associated fibrosis in PVR. This beneficial effect could be partially attributed to the suppression of excessive mesenchymal reactions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-021-05824-0.
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spelling pubmed-85618462021-11-03 Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells Igarashi, Kyoko Sugimoto, Koji Hirano, Eiichi BMC Res Notes Research Note OBJECTIVE: Epithelial–mesenchymal transition (EMT) is involved in the development of proliferative vitreoretinopathy (PVR) and subsequent fibrosis. Previously, we demonstrated that placental extract ameliorates fibrosis in a mouse model of non-alcoholic steatohepatitis. In this study, we evaluated whether placental extract influences EMT and fibrosis through cytokine-induced EMT in the retinal pigment epithelial cells, in vitro. RESULTS: Placental extract did not inhibit EMT, but it suppressed excessive mesenchymal reactions and the subsequent fibrosis. These results suggest that placental extract effectively ameliorates EMT-associated fibrosis in PVR. This beneficial effect could be partially attributed to the suppression of excessive mesenchymal reactions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-021-05824-0. BioMed Central 2021-11-02 /pmc/articles/PMC8561846/ /pubmed/34727968 http://dx.doi.org/10.1186/s13104-021-05824-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Igarashi, Kyoko
Sugimoto, Koji
Hirano, Eiichi
Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
title Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
title_full Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
title_fullStr Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
title_full_unstemmed Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
title_short Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells
title_sort placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in arpe-19 cells
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561846/
https://www.ncbi.nlm.nih.gov/pubmed/34727968
http://dx.doi.org/10.1186/s13104-021-05824-0
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AT sugimotokoji placentalextractsuppressestheformationoffibroticdepositsbytumornecrosisfactoralphaandtransforminggrowthfactorbetainducedepithelialmesenchymaltransitioninarpe19cells
AT hiranoeiichi placentalextractsuppressestheformationoffibroticdepositsbytumornecrosisfactoralphaandtransforminggrowthfactorbetainducedepithelialmesenchymaltransitioninarpe19cells

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