Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

BACKGROUND: Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO is effective to improve anemia, no reliable R...

Descripción completa

Detalles Bibliográficos
Autores principales: Shih, Hong-Mou, Pan, Szu-Yu, Wu, Chih-Jen, Chou, Yu-Hsiang, Chen, Chun-Yuan, Chang, Fan-Chi, Chen, Yi-Ting, Chiang, Wen-Chih, Tsai, Hsing-Chen, Chen, Yung-Ming, Lin, Shuei-Liong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561873/
https://www.ncbi.nlm.nih.gov/pubmed/34724959
http://dx.doi.org/10.1186/s12929-021-00770-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561873/
https://www.ncbi.nlm.nih.gov/pubmed/34724959
http://dx.doi.org/10.1186/s12929-021-00770-2

Ejemplares similares