Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

BACKGROUND: Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO is effective to improve anemia, no reliable R...

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Detalles Bibliográficos
Autores principales: Shih, Hong-Mou, Pan, Szu-Yu, Wu, Chih-Jen, Chou, Yu-Hsiang, Chen, Chun-Yuan, Chang, Fan-Chi, Chen, Yi-Ting, Chiang, Wen-Chih, Tsai, Hsing-Chen, Chen, Yung-Ming, Lin, Shuei-Liong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561873/
https://www.ncbi.nlm.nih.gov/pubmed/34724959
http://dx.doi.org/10.1186/s12929-021-00770-2

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