Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL

B-cell acute lymphoblastic leukemia (B-ALL) results from the expansion of malignant lymphoid precursors within the bone marrow (BM), where hematopoietic niches and microenvironmental signals provide leukemia-initiating cells (LICs) the conditions to survive, proliferate, initiate disease, and relaps...

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Detalles Bibliográficos
Autores principales: Balandrán, Juan Carlos, Dávila-Velderrain, José, Sandoval-Cabrera, Antonio, Zamora-Herrera, Gabriela, Terán-Cerqueda, Vanessa, García-Stivalet, Lilia Adela, Limón-Flores, José Alejandro, Armenta-Castro, Erick, Rodríguez-Martínez, Aurora, Leon-Chavez, Bertha Alicia, Vallejo-Ruiz, Verónica, Hassane, Duane C., Pérez-Tapia, Sonia Mayra, Ortiz-Navarrete, Vianney, Guzman, Monica L., Pelayo, Rosana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561951/
https://www.ncbi.nlm.nih.gov/pubmed/34737747
http://dx.doi.org/10.3389/fimmu.2021.746492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561951/
https://www.ncbi.nlm.nih.gov/pubmed/34737747
http://dx.doi.org/10.3389/fimmu.2021.746492

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