Restarted replication forks are error-prone and cause CAG repeat expansions and contractions

Disease-associated trinucleotide repeats form secondary DNA structures that interfere with replication and repair. Replication has been implicated as a mechanism that can cause repeat expansions and contractions. However, because structure-forming repeats are also replication barriers, it has been u...

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Detalles Bibliográficos
Autores principales: Gold, Michaela A., Whalen, Jenna M., Freon, Karine, Hong, Zixin, Iraqui, Ismail, Lambert, Sarah A. E., Freudenreich, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562783/
https://www.ncbi.nlm.nih.gov/pubmed/34673780
http://dx.doi.org/10.1371/journal.pgen.1009863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562783/
https://www.ncbi.nlm.nih.gov/pubmed/34673780
http://dx.doi.org/10.1371/journal.pgen.1009863

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