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Restarted replication forks are error-prone and cause CAG repeat expansions and contractions
Disease-associated trinucleotide repeats form secondary DNA structures that interfere with replication and repair. Replication has been implicated as a mechanism that can cause repeat expansions and contractions. However, because structure-forming repeats are also replication barriers, it has been u...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562783/ https://www.ncbi.nlm.nih.gov/pubmed/34673780 http://dx.doi.org/10.1371/journal.pgen.1009863 |