Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

One strategy for a functional cure of HIV-1 is “block and lock”, which seeks to permanently suppress the rebound of quiescent HIV-1 by epigenetic silencing. For the bivalent promoter in the HIV LTR, both histone 3 lysine 27 tri-methylation (H3K27me3) and DNA methylation are associated with viral sup...

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Detalles Bibliográficos
Autores principales: Nguyen, Kien, Dobrowolski, Curtis, Shukla, Meenakshi, Cho, Won-Kyung, Luttge, Benjamin, Karn, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562785/
https://www.ncbi.nlm.nih.gov/pubmed/34673825
http://dx.doi.org/10.1371/journal.ppat.1010014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562785/
https://www.ncbi.nlm.nih.gov/pubmed/34673825
http://dx.doi.org/10.1371/journal.ppat.1010014

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