In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)

Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis growth. It is conserved between mycobacterium species, is up-regulated during dormancy, has a known 3D crystal structure...

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Detalles Bibliográficos
Autores principales: Cloete, Ruben, Shahbaaz, Mohd, Grobbelaar, Melanie, Sampson, Samantha L., Christoffels, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562812/
https://www.ncbi.nlm.nih.gov/pubmed/34727137
http://dx.doi.org/10.1371/journal.pone.0259348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562812/
https://www.ncbi.nlm.nih.gov/pubmed/34727137
http://dx.doi.org/10.1371/journal.pone.0259348

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