Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ

Major Histocompatibility Complex Class II (MHCII) is dynamically expressed on intestinal epithelial cells (IECs) throughout the intestine, but its regulation remains poorly understood. We observed that spontaneous upregulation of IEC MHCII in locally-bred Rag1(−/−) mice correlated with serum Interle...

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Detalles Bibliográficos
Autores principales: Van Der Kraak, L. A., Schneider, C., Dang, V., Burr, A.H.P., Weiss, E.S., Varghese, J,A., Yang, L., Hand, T.W., Canna, S.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562907/
https://www.ncbi.nlm.nih.gov/pubmed/34103660
http://dx.doi.org/10.1038/s41385-021-00419-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562907/
https://www.ncbi.nlm.nih.gov/pubmed/34103660
http://dx.doi.org/10.1038/s41385-021-00419-1

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