RNA splicing programs define tissue compartments and cell types at single-cell resolution

The extent splicing is regulated at single-cell resolution has remained controversial due to both available data and methods to interpret it. We apply the SpliZ, a new statistical approach, to detect cell-type-specific splicing in >110K cells from 12 human tissues. Using 10X Chromium data for dis...

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Detalles Bibliográficos
Autores principales: Olivieri, Julia Eve, Dehghannasiri, Roozbeh, Wang, Peter L, Jang, SoRi, de Morree, Antoine, Tan, Serena Y, Ming, Jingsi, Ruohao Wu, Angela, Quake, Stephen R, Krasnow, Mark A, Salzman, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563012/
https://www.ncbi.nlm.nih.gov/pubmed/34515025
http://dx.doi.org/10.7554/eLife.70692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563012/
https://www.ncbi.nlm.nih.gov/pubmed/34515025
http://dx.doi.org/10.7554/eLife.70692

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