EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions

The subcellular localization of RAS GTPases defines the operational compartment of the EGFR-ERK1/2 signaling pathway within cells. Hence, we used live-cell imaging to demonstrate that endogenous KRAS and NRAS tagged with mNeonGreen are predominantly localized to the plasma membrane. NRAS was also pr...

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Detalles Bibliográficos
Autores principales: Surve, Sachin, Watkins, Simon C., Sorkin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563293/
https://www.ncbi.nlm.nih.gov/pubmed/34515735
http://dx.doi.org/10.1083/jcb.202107103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563293/
https://www.ncbi.nlm.nih.gov/pubmed/34515735
http://dx.doi.org/10.1083/jcb.202107103

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