Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism

Structural maintenance of chromosomes (SMC) complexes organize genome topology in all kingdoms of life and have been proposed to perform this function by DNA loop extrusion. How this process works is unknown. Here, we have analyzed how loop extrusion is mediated by human cohesin-NIPBL complexes, whi...

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Detalles Bibliográficos
Autores principales: Bauer, Benedikt W., Davidson, Iain F., Canena, Daniel, Wutz, Gordana, Tang, Wen, Litos, Gabriele, Horn, Sabrina, Hinterdorfer, Peter, Peters, Jan-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563363/
https://www.ncbi.nlm.nih.gov/pubmed/34624221
http://dx.doi.org/10.1016/j.cell.2021.09.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563363/
https://www.ncbi.nlm.nih.gov/pubmed/34624221
http://dx.doi.org/10.1016/j.cell.2021.09.016

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