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A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers
Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC delivery at the site of injection, reducing such toxicity. This work reports the development of NLC loading 4% TTC....
Autores principales: | Castro, Simone R., Ribeiro, Lígia N. M., Breitkreitz, Márcia C., Guilherme, Viviane A., Rodrigues da Silva, Gustavo H., Mitsutake, Hery, Alcântara, Ana C. S., Yokaichiya, Fabiano, Franco, Margareth K. K. D., Clemens, Daniel, Kent, Ben, Lancellotti, Marcelo, de Araújo, Daniele R., de Paula, Eneida |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563806/ https://www.ncbi.nlm.nih.gov/pubmed/34728779 http://dx.doi.org/10.1038/s41598-021-99743-6 |
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