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N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is characterized by high recurrence and heterogeneity, yet its mechanism is not well understood. Here we show that N(1)-methyladenosine methylation (m(1)A) in tRNA is remarkably elevated in hepatocellular carcinoma...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563902/ https://www.ncbi.nlm.nih.gov/pubmed/34728628 http://dx.doi.org/10.1038/s41467-021-26718-6 |