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N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is characterized by high recurrence and heterogeneity, yet its mechanism is not well understood. Here we show that N(1)-methyladenosine methylation (m(1)A) in tRNA is remarkably elevated in hepatocellular carcinoma...

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Detalles Bibliográficos
Autores principales:	Wang, Yanying, Wang, Jing, Li, Xiaoyu, Xiong, Xushen, Wang, Jianyi, Zhou, Ziheng, Zhu, Xiaoxiao, Gu, Yang, Dominissini, Dan, He, Lei, Tian, Yong, Yi, Chengqi, Fan, Zusen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563902/ https://www.ncbi.nlm.nih.gov/pubmed/34728628 http://dx.doi.org/10.1038/s41467-021-26718-6

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