The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids

Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4. Although many natural FFAR4 ligands have carboxyl groups, PHS does not, thus suggesting that binding to FFAR4 is driven b...

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Detalles Bibliográficos
Autores principales: Nagasawa, Tomotaka, Horitani, Masaki, Kawaguchi, Shin‐ichi, Higashiyama, Shigeki, Hama, Yoichiro, Mitsutake, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564095/
https://www.ncbi.nlm.nih.gov/pubmed/34535977
http://dx.doi.org/10.1002/2211-5463.13301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564095/
https://www.ncbi.nlm.nih.gov/pubmed/34535977
http://dx.doi.org/10.1002/2211-5463.13301

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