Cargando…

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids

Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4. Although many natural FFAR4 ligands have carboxyl groups, PHS does not, thus suggesting that binding to FFAR4 is driven b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagasawa, Tomotaka, Horitani, Masaki, Kawaguchi, Shin‐ichi, Higashiyama, Shigeki, Hama, Yoichiro, Mitsutake, Susumu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564095/ https://www.ncbi.nlm.nih.gov/pubmed/34535977 http://dx.doi.org/10.1002/2211-5463.13301

Ejemplares similares

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4
por: Kamata, Ryo, et al.
Publicado: (2016)

FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids
por: Pærregaard, Simone Isling, et al.
Publicado: (2016)

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
por: Husted, Anna Sofie, et al.
Publicado: (2020)

GPR120/FFAR4 Pharmacology: Focus on Agonists in Type 2 Diabetes Mellitus Drug Discovery
por: Carullo, Gabriele, et al.
Publicado: (2021)

Polymorphisms in FFAR4 (GPR120) Gene Modulate Insulin Levels and Sensitivity after Fish Oil Supplementation
por: Vallée Marcotte, Bastien, et al.
Publicado: (2017)

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans
por: Stone, Virginia M., et al.
Publicado: (2014)

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice
por: Nakamoto, Kazuo, et al.
Publicado: (2017)

Cloning, Identification and Functional Characterization of Bovine Free Fatty Acid Receptor-1 (FFAR1/GPR40) in Neutrophils
por: Manosalva, Carolina, et al.
Publicado: (2015)

FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing
por: Ang, Zhiwei, et al.
Publicado: (2018)

Molecular characterization of free fatty acid receptors FFAR2 and FFAR3 in the domestic cat
por: Yamamoto, Ichiro, et al.
Publicado: (2020)

Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
por: Lückmann, Michael, et al.
Publicado: (2019)

Omega-3 Fatty Acids and FFAR4
por: Oh, Da Young, et al.
Publicado: (2014)

Antimicrobial effect of phytosphingosine in acrylic resin
por: Pejon, Luiza Sanchez, et al.
Publicado: (2023)

The Role of GPR120 Receptor in Essential Fatty Acids Metabolism in Schizophrenia
por: Rog, Joanna, et al.
Publicado: (2020)

PT640. The dysfunction of brain free fatty acid receptor GPR40/FFAR1 signaling relate to the development of chronic pain
por: Nakamoto, Kazuo, et al.
Publicado: (2016)

PS04. The changes of emotional behavior in a free fatty acid receptor 1, GPR40/FFAR1, deficient mice
por: Aizawa, Fuka, et al.
Publicado: (2016)

Evaluation of the hepatotoxicity of the novel GPR40 (FFAR1) agonist CPL207280 in the rat and monkey
por: Bazydlo-Guzenda, Katarzyna, et al.
Publicado: (2021)

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation
por: Dragano, Nathalia R. V., et al.
Publicado: (2017)

Molecular mechanism of fatty acid activation of FFAR1
por: Kumari, Punita, et al.
Publicado: (2023)

Effect of short chain fatty acids on the expression of free fatty acid receptor 2 (Ffar2), Ffar3 and early-stage adipogenesis
por: Frost, G, et al.
Publicado: (2014)

Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease
por: Fabisiak, Adam, et al.
Publicado: (2020)

Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells
por: Han, Sang Hee, et al.
Publicado: (2015)

Genetic variants of the unsaturated fatty acid receptor GPR120 relating to obesity in dogs
por: MIYABE, Masahiro, et al.
Publicado: (2015)

A novel free fatty acid receptor 1 (GPR40/FFAR1) agonist, MR1704, enhances glucose‐dependent insulin secretion and improves glucose homeostasis in rats
por: Tsuda, Naoto, et al.
Publicado: (2017)

Regulation of Energy Homeostasis via GPR120
por: Ichimura, Atsuhiko, et al.
Publicado: (2014)

Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet–Induced Metabolic Disease
por: Lan, Hong, et al.
Publicado: (2008)

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice
por: Sadamura, Yuko, et al.
Publicado: (2021)

Revealing a signaling role of phytosphingosine-1-phosphate in yeast
por: Cowart, L Ashley, et al.
Publicado: (2010)

Expression of the Fatty Acid Receptors GPR84 and GPR120 and Cytodifferentiation of Epithelial Cells in the Gastric Mucosa of Mouse Pups in the Course of Dietary Transition
por: Widmayer, Patricia, et al.
Publicado: (2017)

FFA4/GPR120: Pharmacology and Therapeutic Opportunities
por: Milligan, Graeme, et al.
Publicado: (2017)

GPR120 is an important inflammatory regulator in the development of osteoarthritis
por: Chen, Yuanfeng, et al.
Publicado: (2018)

The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)
por: Hudson, Brian D., et al.
Publicado: (2014)

Functional Analysis of Free Fatty Acid Receptor GPR120 in Human Eosinophils: Implications in Metabolic Homeostasis
por: Konno, Yasunori, et al.
Publicado: (2015)

Gpr120 mRNA expression in gonadotropes in the mouse pituitary gland is regulated by free fatty acids
por: DEURA, Chikaya, et al.
Publicado: (2020)

Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science
por: Son, So-Eun, et al.
Publicado: (2021)

Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook
por: Al Mahri, Saeed, et al.
Publicado: (2022)

Anti-Atherosclerotic Potential of Free Fatty Acid Receptor 4 (FFAR4)
por: Kiepura, Anna, et al.
Publicado: (2021)

Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists
por: Ang, Zhiwei, et al.
Publicado: (2016)

The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs
por: Lind, Simon, et al.
Publicado: (2023)

Phytosphingosine induces systemic acquired resistance through activation of sphingosine kinase
por: Seo, So Yeon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cgma7q2hgucl0udn7i3psuoidg