DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease

Huntington disease (HD) is a devastating neurodegenerative disorder characterized by aggregation of huntingtin (HTT) protein containing expanded polyglutamine (polyQ) tracts. DNAJB6, a member of the DNAJ chaperone family, was reported to efficiently inhibit polyQ aggregation in vitro, in cell models...

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Detalles Bibliográficos
Autores principales: Joshi, Bhagyashree S., Youssef, Sameh A., Bron, Reinier, de Bruin, Alain, Kampinga, Harm H., Zuhorn, Inge S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564107/
https://www.ncbi.nlm.nih.gov/pubmed/34755099
http://dx.doi.org/10.1016/j.isci.2021.103282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564107/
https://www.ncbi.nlm.nih.gov/pubmed/34755099
http://dx.doi.org/10.1016/j.isci.2021.103282

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