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Interaction-Based Feature Selection Algorithm Outperforms Polygenic Risk Score in Predicting Parkinson’s Disease Status
Polygenic risk scores (PRS) aggregating results from genome-wide association studies are the state of the art in the prediction of susceptibility to complex traits or diseases, yet their predictive performance is limited for various reasons, not least of which is their failure to incorporate the eff...
Autores principales: | Cope, Justin L., Baukmann, Hannes A., Klinger, Jörn E., Ravarani, Charles N. J., Böttinger, Erwin P., Konigorski, Stefan, Schmidt, Marco F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564367/ https://www.ncbi.nlm.nih.gov/pubmed/34745218 http://dx.doi.org/10.3389/fgene.2021.744557 |
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