A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies

Depression is an umbrella term used to describe a mood disorder with a broad spectrum of symptoms including a persistent feeling of sadness, loss of interest, and deficits in social behavior. Epigenetic research bridges the environmental and genetic landscape and has the potential to exponentially i...

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Autores principales: Cahill, Branden, Poelker-Wells, Samuel, Prather, Jonathan F., Li, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564393/
https://www.ncbi.nlm.nih.gov/pubmed/34744641
http://dx.doi.org/10.3389/fncir.2021.768571
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author Cahill, Branden
Poelker-Wells, Samuel
Prather, Jonathan F.
Li, Yun
author_facet Cahill, Branden
Poelker-Wells, Samuel
Prather, Jonathan F.
Li, Yun
author_sort Cahill, Branden
collection PubMed
description Depression is an umbrella term used to describe a mood disorder with a broad spectrum of symptoms including a persistent feeling of sadness, loss of interest, and deficits in social behavior. Epigenetic research bridges the environmental and genetic landscape and has the potential to exponentially improve our understanding of such a complex disorder. Depression is also a sexually dimorphic disorder and variations exist within epigenetic modification sites between sexes. These sex-specific mediators may impact behavioral symptomology and could serve as therapeutic targets for treatments to improve behavioral deficits. This mini review will focus on the social behavior perspective of depression and specifically explore the sexually different epigenetic modifications on depression.
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spelling pubmed-85643932021-11-04 A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies Cahill, Branden Poelker-Wells, Samuel Prather, Jonathan F. Li, Yun Front Neural Circuits Neural Circuits Depression is an umbrella term used to describe a mood disorder with a broad spectrum of symptoms including a persistent feeling of sadness, loss of interest, and deficits in social behavior. Epigenetic research bridges the environmental and genetic landscape and has the potential to exponentially improve our understanding of such a complex disorder. Depression is also a sexually dimorphic disorder and variations exist within epigenetic modification sites between sexes. These sex-specific mediators may impact behavioral symptomology and could serve as therapeutic targets for treatments to improve behavioral deficits. This mini review will focus on the social behavior perspective of depression and specifically explore the sexually different epigenetic modifications on depression. Frontiers Media S.A. 2021-10-20 /pmc/articles/PMC8564393/ /pubmed/34744641 http://dx.doi.org/10.3389/fncir.2021.768571 Text en Copyright © 2021 Cahill, Poelker-Wells, Prather and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neural Circuits
Cahill, Branden
Poelker-Wells, Samuel
Prather, Jonathan F.
Li, Yun
A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
title A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
title_full A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
title_fullStr A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
title_full_unstemmed A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
title_short A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
title_sort glimpse into the sexual dimorphisms in major depressive disorder through epigenetic studies
topic Neural Circuits
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564393/
https://www.ncbi.nlm.nih.gov/pubmed/34744641
http://dx.doi.org/10.3389/fncir.2021.768571
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