Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart

Type 2 diabetes (T2D) impairs hypoxia-inducible factor (HIF)1α activation, a master transcription factor that drives cellular adaptation to hypoxia. Reduced activation of HIF1α contributes to the impaired post-ischemic remodeling observed following myocardial infarction in T2D. Molidustat is an HIF...

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Detalles Bibliográficos
Autores principales: Sousa Fialho, Maria da Luz, Purnama, Ujang, Dennis, Kaitlyn M.J.H., Montes Aparicio, Claudia N., Castro-Guarda, Marcos, Massourides, Emmanuelle, Tyler, Damian J., Carr, Carolyn A., Heather, Lisa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564414/
https://www.ncbi.nlm.nih.gov/pubmed/34526367
http://dx.doi.org/10.2337/db21-0398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564414/
https://www.ncbi.nlm.nih.gov/pubmed/34526367
http://dx.doi.org/10.2337/db21-0398

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