Investigation of Praziquantel/Cyclodextrin Inclusion Complexation by NMR and LC-HRMS/MS: Mechanism, Solubility, Chemical Stability, and Degradation Products

[Image: see text] Praziquantel (PZQ) is a biopharmaceutical classification system (BCS) class II anthelmintic drug characterized by poor solubility and a bitter taste, both of which can be addressed by inclusion complexation with cyclodextrins (CD). In this work, a comprehensive investigation of pra...

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Detalles Bibliográficos
Autores principales: Špehar, Tatjana Kezele, Pocrnić, Marijana, Klarić, David, Bertoša, Branimir, Čikoš, Ana, Jug, Mario, Padovan, Jasna, Dragojević, Snježana, Galić, Nives
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564759/
https://www.ncbi.nlm.nih.gov/pubmed/34670371
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564759/
https://www.ncbi.nlm.nih.gov/pubmed/34670371
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00716

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