Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy

The expression of BRAF‐V600E triggers oncogene‐induced senescence in normal cells and is implicated in the development of several cancers including melanoma. Here, we report that cardioglycosides such as ouabain are potent senolytics in BRAF senescence. Sensitization by ATP1A1 knockdown and protecti...

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Detalles Bibliográficos
Autores principales: L’Hôte, Valentin, Courbeyrette, Régis, Pinna, Guillaume, Cintrat, Jean‐Christophe, Le Pavec, Gwenaëlle, Delaunay‐Moisan, Agnès, Mann, Carl, Thuret, Jean‐Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564827/
https://www.ncbi.nlm.nih.gov/pubmed/34355491
http://dx.doi.org/10.1111/acel.13447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564827/
https://www.ncbi.nlm.nih.gov/pubmed/34355491
http://dx.doi.org/10.1111/acel.13447

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