Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses

B cell clones compete for entry into and dominance within germinal centers (GCs), where the highest-affinity B cell receptors (BCRs) are selected. However, diverse and low-affinity B cells can enter and reside in GCs for extended periods. To reconcile these observations, we hypothesize that a negati...

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Detalles Bibliográficos
Autores principales: Brooks, Jeremy F., Tan, Corey, Mueller, James L., Hibiya, Kenta, Hiwa, Ryosuke, Vykunta, Vivasvan, Zikherman, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564879/
https://www.ncbi.nlm.nih.gov/pubmed/34469720
http://dx.doi.org/10.1016/j.celrep.2021.109645

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564879/
https://www.ncbi.nlm.nih.gov/pubmed/34469720
http://dx.doi.org/10.1016/j.celrep.2021.109645

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