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Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses
B cell clones compete for entry into and dominance within germinal centers (GCs), where the highest-affinity B cell receptors (BCRs) are selected. However, diverse and low-affinity B cells can enter and reside in GCs for extended periods. To reconcile these observations, we hypothesize that a negati...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564879/ https://www.ncbi.nlm.nih.gov/pubmed/34469720 http://dx.doi.org/10.1016/j.celrep.2021.109645 |