Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency

The prevailing view is that the ClC-Ka chloride channel (mouse Clc-k1) functions in the thin ascending limb to control urine concentration, whereas the ClC-Kb channel (mouse Clc-k2) functions in the thick ascending limb (TAL) to control salt reabsorption. Mutations of ClC-Kb cause classic Bartter sy...

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Detalles Bibliográficos
Autores principales: Lin, Meng-Hsuan, Chen, Jen-Chi, Tian, Xuejiao, Lee, Chia-Ming, Yu, I-Shing, Lo, Yi-Fen, Uchida, Shinichi, Huang, Chou-Long, Chen, Bi-Chang, Cheng, Chih-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564913/
https://www.ncbi.nlm.nih.gov/pubmed/34499620
http://dx.doi.org/10.1172/jci.insight.151039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8564913/
https://www.ncbi.nlm.nih.gov/pubmed/34499620
http://dx.doi.org/10.1172/jci.insight.151039

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