TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist

Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to chemotherapy and are not amenable to surgical resection, it is imperative to develop new the...

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Detalles Bibliográficos
Autores principales: Xu, Cheng, Liu, Heng, Pirozzi, Christopher J., Chen, Lee H., Greer, Paula K., Diplas, Bill H., Zhang, Liwei, Waitkus, Matthew S., He, Yiping, Yan, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565061/
https://www.ncbi.nlm.nih.gov/pubmed/34732238
http://dx.doi.org/10.1186/s40478-021-01270-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565061/
https://www.ncbi.nlm.nih.gov/pubmed/34732238
http://dx.doi.org/10.1186/s40478-021-01270-y

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